Health

Mounjaro (Tirzepatide) Linked to Dramatic Weight Loss in New Study

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Tirzepatide, the active ingredient in the diabetes drug Mounjaro, helped people lose more than 60 pounds (lb), or at least one-quarter of their body weight, when used along with intensive lifestyle changes, according to a new study.

Researchers asked 806 obese or overweight participants without type 2 diabetes to dramatically overhaul their eating and exercise habits for three months. Aided by a low-calorie diet and frequent counseling sessions, a total of 579 people managed to reduce their body weight by at least 5 percent. Scientists then randomly assigned individuals in this group to take weekly injections of tirzepatide or a placebo for 72 weeks.

At the start of the study, people weighed an average of 241 lb. By the end, those on tirzepatide lost almost 27 percent of their total body weight on average, or about 64 pounds, according to the results, published in Nature Medicine. By comparison, participants who got placebo shots shed 9 lb, or about 4 percent of their weight.

“The results seen with tirzepatide are the best seen so far with any anti-obesity medication and are similar to results seen at one year with bariatric surgery,” says Adam Gilden, MD, an associate professor and the associate director of the weight management and wellness clinic at the University of Colorado School of Medicine in Aurora, who wasn’t involved in the new study.

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