Health
Enthesitis in Psoriatic Arthritis: Symptoms, Causes, and Treatment
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Research is ongoing into the most effective treatment of enthesitis in people with psoriatic arthritis.
In a research study, researchers compared the effectiveness of NSAIDs, conventional disease-modifying antirheumatic drugs (DMARDs), and biologic drugs in relieving enthesitis in a group of 526 participants with psoriatic arthritis. They found that 453 (86.1 percent) experienced complete resolution of their enthesitis over an average duration of 8.73 months, and that a similar rate of resolution was seen regardless of which of the three types of drugs the participants took.
But according to reporting by the Arthritis Foundation, enthesitis often does not respond well to conventional DMARDs commonly used to treat psoriatic arthritis, such as methotrexate and leflunomide.
Instead, as a first step, your doctor may prescribe a high dose of a nonsteroidal anti-inflammatory drug (NSAID) such as naproxen or indomethacin. But high doses of these drugs can only be taken for up to about a month, and they’re not an option for many people, such as those with a history of certain gastrointestinal problems like ulcers.
If you have enthesitis in only one location, your doctor may inject a steroid in the area to help reduce inflammation.
If you have enthesitis in multiple locations, you may need to take a biologic drug, such as a TNF inhibitor, for long-term treatment.
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